Prayagraj: A team of 11 scientists from the Cleveland Clinic in the US and a researcher from the University of Allahabad (AU) has discovered a method that would not require chemo and radiation therapy to kill cancer cells.
The team’s work, led by Yang Li, professor of cancer biology at the Cleveland Clinic, and with the assistance of Munish Pandey, assistant professor in the Department of Biochemistry, AU, has been published in the prestigious journal ‘Oncogene by Nature’.
This research is also important because the work offers promising treatments that can be used to protect cancer patients from the side effects of chemo and radiation therapy.
After its successful use on rats, efforts are now being intensified to apply it on the human body.
Pandey said: “The study may bring relief to a cancer patient who undergoes chemotherapy. Chemotherapy uses radiation and other drugs that have many side effects and stimulate the immune system that causes severe pain and an allergic reaction The team has previously developed knockout mice for miR-21. And this was published in the ‘Proceedings of the National Academy of Sciences’ of the US (PNAS) journal microRNA-21 (small non-coding RNA) mammalian It is one of the most abundant microRNAs in cells that regulate apoptosis (programmed cell death) and oncogenic effects.
“I have worked with American scientists and invented alternatives to chemotherapy and drugs in the treatment of cancer, which damage cancer cells as well as normal cells during cancer treatment. This successful experiment was conducted at the Cleveland Clinic. was done by a team of 11 scientists. and Yang Li. Using mice, our team injected its anti-sense into mice to render miR-21 ineffective.”
After this it was found that the tumor formed in the body of the rat gradually got smaller and some tumors disappeared completely.
This experiment lasted for a year in America. However, it has not yet been used on the human body. Now the effort to apply it on the human body has been intensified.
He said that due to cancer, tumors are formed in the body, which are eliminated through chemotherapy and medicines. In this process of treatment, cancer cells as well as normal cells are damaged and this has a negative effect on the body.
The group is working on other programmed cell death mechanisms, microRNAs and chimeric antigen T-cell therapy to combat carcinogenicity in mice models.
Read Full Article
';
$('div.listing').append(string);
}
});
},
error:function(xhr){
//console.log("Error");
//console.log("An error occured: " + xhr.status + " " + xhr.statusText);
nextload=false;
},
complete: function(){
$('div.listing').find(".loading-block").remove();;
pg +=1;
//console.log("mod" + ice%2);
nextpath="&page=" + pg;
//console.log("request complete" + nextpath);
cat = "?cat=120172";
//console.log(nextpath);
nextload=(ice%2==0)?true:false;
}
});
}
//lastoff = last.offset();
//console.log("**" + lastoff + "**");
});*/
var maindiv = false;
var dis = 0;
var fbcontainer="";
var fbid = '';
var fb_script=document.createElement('script');
fb_script.text= "(function(d, s, id) {var js, fjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) return;js = d.createElement(s); js.id = id;js.src="https://connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9";fjs.parentNode.insertBefore(js, fjs);}(document, 'script', 'facebook-jssdk'));";
var fmain = $(".sr2423378");
//alert(x+ "-" + url);
var fdiv = '
';
//console.log(fdiv);
//$(fb_script).appendTo(fmain);
$(fdiv).appendTo(fmain);
function fillElementWithAd($el, slotCode, size, targeting){
if (typeof targeting === 'undefined') {
targeting = {};
} else if ( Object.prototype.toString.call( targeting ) !== '[object Object]' ) {
targeting = {};
}
var elId = $el.attr('id');
//console.log("elId:" + elId);
googletag.cmd.push(function(){
var slot = googletag.defineSlot(slotCode, size, elId);
for (var t in targeting){
slot.setTargeting(t, targeting
}
slot.addService(googletag.pubads());
googletag.display(elId);
//googletag.pubads().refresh([slot]);
});
}
$(document).delegate("button[id^='mf']", "click", function(){
fbcontainer="";
fbid = '#' + $(this).attr('id');
var sr = fbid.replace("#mf", ".sr");
$(fbid).parent().children(sr).toggle();
fbcontainer = $(fbid).parent().children(sr).children(".fb-comments").attr("id");
});
function onPlayerStateChange(event){
var ing, fid;
//console.log(event + "---player");
$('iframe[id*="video-"]').each(function(){
_v = $(this).attr('id');
//console.log("_v: " + _v);
if(_v != event){
//console.log("condition match");
ing = new YT.get(_v);
if(ing.getPlayerState()=='1'){
ing.pauseVideo();
}
}
});
$('div[id*="video-"]').each(function(){
_v = $(this).attr('id');
//console.log("_v: " + _v + " event: " + event);
if(_v != event){
//jwplayer(_v).play(false);
}
});
}
function onYouTubePlay(vid, code, playDiv,vx, pvid){
if (typeof(YT) == 'undefined' || typeof(YT.Player) == 'undefined') {
var tag = document.createElement('script');
tag.src = "https://www.youtube.com/iframe_api";
var firstScriptTag = document.getElementsByTagName('script')[0];
firstScriptTag.parentNode.insertBefore(tag, firstScriptTag);
window.onYouTubePlayerAPIReady = function() {
onYouTubePlayer(vid, code, playDiv,vx, pvid);
};
}else{onYouTubePlayer(vid, code, playDiv,vx, pvid);}
}
function onYouTubePlayer(vid, code, playDiv,vx, pvid){
//console.log(playDiv + "Get Youtue " + vid);
//$("#"+vid).find(".playvideo-"+ vx).hide();
var player = new YT.Player(playDiv , {
height: '450',
width: '100%',
videoId:code,
playerVars: {
'autoplay': 1,
'showinfo': 1,
'controls': 1
},
events: {
'onStateChange': function(event){
onPlayerStateChange(event.target.a.id);
}
}
});
$("#video-"+vid).show();
}
function kalturaPlayerAPIReady(code, playDiv,pvid){
var dt=new Date;
var nt=dt.getTime();
var vtitle = "";
var video_id_arr = code.split("https://zeenews.india.com/");
var youbora_video_id = video_id_arr[5].split(".");
var youbora_video_id = '"' + youbora_video_id[0] + '"';
pre_roll = "https://pubads.g.doubleclick.net/gampad/ads?sz=640x480&iu=/11440465/Zeenews_English_Video/Zeenews_English_Preroll&tfcd=0&npa=0&sz=640x480&gdfp_req=1&output=vast&unviewed_position_start=1&env=vp&impl=s&description_url="+vtitle+"&correlator="+nt;
var sources ={};
var config = {
targetId: playDiv,
provider: {
partnerId: 2504201
},
playback: {
pictureInPicture : true,
autoplay: true
},
advertising: {
adBreaks: [{
position: 0,
ads: [{
url: [pre_roll]
}]
}]
},
plugins: {
youbora: {
options: {
"content.title": "Chemotherapy may not be needed to treat cancer: Research",
"content.customDimension.1":"Zee News",
"content.customDimension.2":"https://zeenews.india.com/",
"content.customDimension.3":"2021-Dec-28 16:03:16",
"content.customDimension.4":"Tahira Khan",
"content.customDimension.5":"2423378",
"content.customDimension.6":"Health,Cancer,Chemotherapy,Oncology",
"content.id":youbora_video_id,
"content.language":"English"
}
},
ima: {
adsResponse: ""
}
}
}
var kalturaPlayer = KalturaPlayer.setup(config);
if(kalturaPlayer){
kalturaPlayer.reset();
}
var videoUrl = code;
var mediaid = '"zn' + pvid + '"';
sources = {
hls: [{
id: mediaid,
url: videoUrl,
mimetype: "application/x-mpegURL"
}]
}
kalturaplayerSetup(kalturaPlayer, sources);
if (typeof kalturaPlayer !== 'undefined') {
doRegisterEvents(kalturaPlayer);
}
}
function kalturaplayerSetup(kalturaPlayer, playbackType){
kalturaPlayer.setMedia({
plugins: {},
sources: playbackType
});
}
function doRegisterEvents(kalturaPlayer) {
/* player event*/
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAY, playEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PAUSE, pauseEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAYBACK_ENDED, playbackEndedEvent);
/* ad event */
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_STARTED, adStartedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_COMPLETED, adCompletedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_SKIPPED, adSkippedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_CLICKED,adClicked);
}
var vlabel = "https://zeenews.india.com"+$(this).attr("video-path");
var isVideoPlayed = false;
var isAdSkippedCompleted = false;
function adStartedEvent(event) {
var videotype = "zee english video";
gtag('event', 'Adstarted', { 'event_category': videotype, 'event_label': vlabel});
gtag('event', 'Play', { 'event_category': videotype, 'event_label': vlabel});
isVideoPlayed = true;
isAdSkippedCompleted = true;
}
function adCompletedEvent(event) {
var videotype = "zee english video";
gtag('event', 'Adcompleted', { 'event_category': videotype, 'event_label': vlabel});
isAdSkippedCompleted = true;
}
function adSkippedEvent(event) {
var videotype = "zee english video";
gtag('event', 'Adskipped', { 'event_category': videotype, 'event_label': vlabel});
isAdSkippedCompleted = true;
}
function adClicked(event) {
var videotype = "zee english video";
gtag('event', 'Adclicked', { 'event_category': videotype, 'event_label': vlabel});
}
function playbackEndedEvent(event){
var videotype = "zee english video";
gtag('event', 'Complete', { 'event_category': videotype, 'event_label': vlabel});
}
function playEvent(event) {
var videotype = "zee english video";
if((isVideoPlayed) && (isAdSkippedCompleted)){
isAdSkippedCompleted = false;
}else if((isVideoPlayed)){
gtag('event', 'resume', { 'event_category': videotype, 'event_label': vlabel});
}else{
gtag('event', 'Play', { 'event_category': videotype, 'event_label': vlabel});
isVideoPlayed = true;
}
}
function pauseEvent(event) {
var videotype = "zee english video";
gtag('event', 'Pause', { 'event_category': videotype, 'event_label': vlabel});
}
function AdloadEvent(event) {
var videotype = "zee english video";
gtag("event", "kaltura_adloaded", { "event_category": videotype, "event_label": vlabel});
}
function AdProgressEvent(event) {
var videotype = "zee english video";
gtag("event", "kaltura_adprogress", { "event_category": videotype, "event_label": vlabel});
}
function adPausedEvent(event) {
var videotype = "zee english video";
gtag("event", "kaltura_adpaused", { "event_category": videotype, "event_label": vlabel});
}
/* End of Kaltura player function code */
$(document).delegate("div[id^='play']", "click", function(){
//console.log($(this).attr("id"));
//console.log($(this).attr("video-source"));
//console.log($(this).attr("video-code"));
var isyoutube = $(this).attr("video-source");
var vurl = $(this).attr("video-path");
var vid = $(this).attr("id");
$(this).hide();
var pvid = $(this).attr("newsid");
var vx = $(this).attr("id").replace('play-','');
var vC = $(this).attr("video-code");
var playDiv = "video-" + vid + "-" + pvid;
if(isyoutube =='No'){
kalturaPlayerAPIReady(vC, playDiv,pvid);
}else{
onYouTubePlay(vid, vC, playDiv,vx, pvid);
}
});
$(document).delegate("div[id^='ptop']", "click", function(){
var vid = $(this).attr("id").replace('ptop','');
$(this).hide();
var pvid = $(this).attr("newsid");
var vurl = $(this).attr("video-path");
//console.log($(this).attr("id") + "--" + vid);
//console.log($(this).parent().children().find('#play-'+vid).attr("video-source"));
//console.log($(this).parent().children().find('#play-'+vid).attr("video-code"));
var isyoutube = $(this).parent().children().find('#play-'+vid).attr("video-source");
var vC = $(this).parent().children().find('#play-'+vid).attr("video-code");
var playDiv = "mvideo-play-" + vid + "-" + pvid;
if(isyoutube =='No'){
//console.log(jwplayer($(this).attr("id")).getState());
kalturaPlayerAPIReady(vC, playDiv,pvid);
}else{
onYouTubePlay($(this).attr("id"), vC, playDiv, vid, pvid);
}
});
var nxti = 3;
var ci = 1;
var nxti_1 = 6;
var nxti_2 = 9;
var nxti_3 = 12;
if($.autopager==false){
var use_ajax = false;
/*var disqus_shortname="zeehindi";
var disqus_identifier; //made of post id and guid
var disqus_url; //post permalink
function loadDisqus(source, identifier, url, nid) {
if (window.DISQUS) {
//alert("if");
jQuery('
').insertAfter(source);
jQuery('#disqus_thread').insertAfter(source); //append the HTML after the link
//if Disqus exists, call it's reset method with new parameters
DISQUS.reset({
reload: true,
config: function () {
this.page.identifier = identifier;
this.page.url = url;
}
});
}else{
jQuery('
').insertAfter(source);
disqus_identifier = identifier; //set the identifier argument
disqus_url = url; //set the permalink argument
//append the Disqus embed script to HTML
var dsq = document.createElement('script'); dsq.type="text/javascript"; dsq.async = true;
dsq.src="http://" + disqus_shortname + '.disqus.com/embed.js';
jQuery('head').append(dsq);
}
};*/
/*$('.disqusOn').live( "click", notify );
function notify() {
identifier = $(this).attr('id');
dUrl = $(this).attr('disqus-url');
source = $(this).parent();
loadDisqus(jQuery(this), identifier, dUrl);
}*/
function loadshare(curl){
history.replaceState('' ,'', curl);
if(window.OBR){
window.OBR.extern.researchWidget();
}
//console.log("loadshare Call->" + curl);
//$('html head').find('title').text("main" + nxtTitle);
if(_up == false){
var cu_url = curl;
gtag('config', 'UA-2069755-1', {'page_path': cu_url });
if(window.COMSCORE){
window.COMSCORE.beacon({c1: "2", c2: "9254297"});
var e = Date.now();
$.ajax({
url: "/marathi/news/zscorecard.json?" + e,
success: function(e) {}
})
}
//console.log('ga:'+r);
/*(function () {
var ga = document.createElement('script'); ga.type="text/javascript"; ga.async = true;
ga.src = ('https:' == document.location.protocol ? 'https://' : 'http://') + 'stats.g.doubleclick.net/dc.js';
var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s);
})();*/
//console.log("loadshare Call");
}
}
if(use_ajax==false) {
//console.log('getting');
var view_selector="div.center-section"; // + settings.view_name; + '.view-display-id-' + settings.display;
var content_selector = view_selector; // + settings.content_selector;
var items_selector = content_selector + ' > div.rep-block'; // + settings.items_selector;
var pager_selector="div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix"; // + settings.pager_selector;
var next_selector="div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix > a:last"; // + settings.next_selector;
var auto_selector="div.tag-block";
var img_location = view_selector + ' > div.rep-block:last';
var img_path="
Loading
"; //settings.img_path;
//var img = '
' + img_path + '
';
var img = img_path;
//$(pager_selector).hide();
//alert($(next_selector).attr('href'));
var x = 0;
var url="";
var prevLoc = window.location.pathname;
var circle = "";
var myTimer = "";
var interval = 30;
var angle = 0;
var Inverval = "";
var angle_increment = 6;
var handle = $.autopager({
appendTo: content_selector,
content: items_selector,
runscroll: maindiv,
link: next_selector,
autoLoad: false,
page: 0,
start: function(){
$(img_location).after(img);
circle = $('.center-section').find('#green-halo');
myTimer = $('.center-section').find('#myTimer');
angle = 0;
Inverval = setInterval(function (){
$(circle).attr("stroke-dasharray", angle + ", 20000");
//myTimer.innerHTML = parseInt(angle/360*100) + '%';
if (angle >= 360) {
angle = 1;
}
angle += angle_increment;
}.bind(this),interval);
},
load: function(){
$('div.loading-block').remove();
clearInterval(Inverval);
//$('.repeat-block > .row > div.main-rhs2423378').find('div.rhs2423378:first').clone().appendTo('.repeat-block >.row > div.main-rhs' + x);
$('div.rep-block > div.main-rhs2423378 > div:first').clone().appendTo('div.rep-block > div.main-rhs' + x);
$('.center-section >.row:last').before('