Washington [US]Oct 7 (ANI): A new bandage treatment known as staging for the treatment of diabetic foot ulcers, which is cost-effective while improving patient outcomes, has been designed by researchers at Queen’s University Belfast.
Created by 3D bioprinting, the scaffolds gradually release antibiotics over a period of four weeks to effectively treat the wound. The study was published in the journal Drug Delivery and Translational Research.
Diabetes, a lifelong condition that causes a person’s blood sugar level to become too high, is one of the top ten causes of death worldwide.
Diabetic foot ulcer (DFU), a serious complication of diabetes, affects about 25% of diabetics. When identified, more than 50 percent are already infected and more than 70 percent of cases result in amputation of the lower limbs.
The treatment strategy required for effective treatment of DFU is a complex process that requires multiple combined therapeutic approaches. Consequently, there is a significant clinical and economic burden associated with the treatment of DFU. These treatments are often unsuccessful, leading to lower limb amputation.
This new research demonstrates consequences for reducing the cost and clinical burden in treating DFU, along with important implications for patient quality of life.
Recent research has focused on drug-filled scaffolds to treat DFU. The scaffold structure is a new carrier for cell and drug delivery that enhances wound healing.
The research, published in Springer Link, will be presented by Professor Lampro at the Controlled Release Society (CRS) workshop Italy (7 – 9 October).
Professor Dimitrios Lampro, Professor of Biofabrication and Advanced Manufacturing at the Queens School of Pharmacy and corresponding author, explains: “These scaffolds are like windows that enable doctors to monitor treatments continuously. This avoids the need to remove them constantly. , which can provoke infection and delay the healing process.
The “frame” contains an antibiotic that helps to ‘kill’ the bacterial infection, and the ‘glass’ which can be framed by collagen/sodium alginate may contain a growth factor to stimulate cell growth The scaffold consists of two molecular layers that both play an important role in wound healing.”
Lead author Ms Katie Glover, from Queen’s School of Pharmacy, concluded: “Using bioprinting technology, we have developed a scaffold with suitable mechanical properties for wound healing, which can be easily modified into wound shape “
Glover said, “This provides a low-cost alternative to current DFU therapies that could revolutionize DFU treatment, improving patient outcomes while reducing the rapidly increasing economic burden of patient demand.” Because the number of people with diabetes is increasing every year.” (ANI)
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