Vaccines reduce hospitalization risk by 70%, Lancet study finds on breakthrough infection

File photo of a person being vaccinated against Kovid in Delhi. Manisha Mandal | impression

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New Delhi: A UK study says that vaccination can reduce the risk of hospitalization due to Kovid by about 70 percent and the risk of serious illness by up to a third. published In lancet infectious disease magazine.

Released on Thursday, the large-scale study – led by King’s College London, and involving researchers from University College London, Massachusetts General Hospital and Harvard Medical School – looked at breakthrough COVID infections in the UK. The study used data from a smartphone-based COVID symptom tracking app collected from 8 December 2020 to 4 July 2021.

Among other things, the researchers found that the likelihood of experiencing a prolonged COVID – an illness lasting 28 days or more after a positive test – was cut in half for people who received two vaccine doses.

Breakthrough COVID infections are those that occur in people who have been partially or fully vaccinated.

According to the study, those most vulnerable to a successful infection after the first dose of the vaccine included adults over the age of 60, especially those with underlying conditions such as obesity, heart disease, kidney disease and lung disease. living with the conditions.

The study also showed that people in densely populated urban settings were more likely to experience a successful transition.

One of the study’s authors, Claire Steves of King’s College London, said: “Successful infections are expected and do not diminish the fact that these vaccines are doing what they were designed to do. To save and prevent serious disease.” a statement.

“Other research has linked the mortality rate for hospitalized Covid-19 patients to 27 per cent. We can greatly reduce that number through vaccination by keeping people out of the hospital in the first place,” Steves said.


Read also: What is the newly discovered C.1.2 lineage of SARS-CoV-2 and why is it not yet ‘a matter of concern’?


‘0.2% of fully immunized persons infected with COVID’

Of more than 12,40,009 adults who received at least one dose of BNT162b2 (Pfizer-BioNtech), ChAdOx1 nCoV-19 (Oxford-AstraZeneca), or mRNA-1273 (Moderna) vaccine, 6,030 — or less than 0.5 per cent — reported a successful transition more than 14 days after their first dose, the researchers said.

Meanwhile, of the 9,71,504 adults who received two doses of the vaccine, 2,370 — less than 0.2 percent — experienced a successful infection seven days after their second dose.

According to the study, the chances of a successful infection being asymptomatic increased by 63 percent after one dose of one vaccine and by 94 percent after the second dose.

The risk of hospitalization was also reduced by about 70 percent after one or two doses.

The risk of severe illness, defined as having five or more symptoms in the first week of illness, was also reduced by a third. Additionally, the likelihood of long-term covid was reduced by 50 percent after two doses.

People who experienced symptoms after one or two doses of the vaccine, such as fatigue, cough, fever and loss of taste and smell, were almost all reported less frequently than those who were not vaccinated.

In vulnerable older adults over the age of 60, the risk of a successful infection following a single dose of vaccine was nearly twice that for healthy older adults.

The researchers also noted that the risk of a successful infection was linked to the location where a person lived.

People living in disadvantaged areas such as close living quarters and low overall vaccination rates had the highest risk of a successful infection after their first vaccine dose.

Researchers say these results are not unexpected and reflect what has been observed throughout the pandemic.

“These groups are at greater risk of exposure and are therefore more vulnerable to infection. One of the study’s authors, Rose Penfold of King’s College, London, said health policies designed to prevent infections, including policies around the time between the first and second doses and potential booster shots, should prioritize these groups. .

(Edited by Rachel John)


Read also: Ensure all teachers get at least one dose of vaccine by September, Modi govt tells states, UTs


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