London: UK drugmaker AstraZeneca has partnered with scientists from Imperial College London to develop a new vaccine technology to treat cancer, heart disease and other non-communicable diseases and ailments.
The technology was originally intended to target COVID-19 and works by delivering genetic material called self-amplifying RNA to human cells. The cells are then trained to recognize and respond to infection, The Independent reported.
Imperial scientists aimed to use the technology to design a COVID-19 jab. However, it never progressed beyond a phase two clinical trial.
“We have clinical data that is good for the technology but needs improvement,” said Professor Robin Shattock, an immunologist at Imperial.
“AstraZeneca wants to take our approach and drive it forward. They see the potential of the platform.”
In addition to producing antibodies against the spike protein structure found on the surface of SARS-CoV-2 and a protective layer of T-cells, the unique platform uses self-amplifying RNA to self-amplify once injected into humans. Copies can also be made, so that more can be produced. real message.
The team hopes that the same technology can be used to teach the body to recognize other foreign threats or internal malfunctions, such as cancer, and then neutralize them through trained immunological cells.
Shattock said his team, along with experts at AstraZeneca, will work to apply the self-amplifying RNA to a variety of disease areas.
He said there were no plans for human trials at this stage, with the first focusing on customizing the vaccine platform in the laboratory and determining whether it would be successful in treating cancer or heart disease.
The report said the agreement with AstraZeneca will support the Imperial team with research and development funding for 26 different drug targets.
“We have all seen how the technologies around RNA are fundamental to preventing ongoing serious illness and death in major global pandemics,” Prof Shattock said. “The potential for further therapeutic applications adds to the great potential of this technology.”
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