Washington: According to a study conducted by a team of researchers from the University of Colorado, drugs used to treat malaria are also effective in treating pulmonary disease such as tuberculosis. This research was published in the journal ‘Science of Translational Medicine’.
The study was an important development in the fight against infections caused by non-tuberculous mycobacteria, or NTMs, which are now more common than tuberculosis in the United States and often attack people who have weakened immune systems or chronic resistant As are pre-existing conditions. Pulmonary disease or cystic fibrosis.
Professor Mary Jackson, one of the lead authors in CSU’s Department of Microbiology, Immunology and Pathology, said, “There are very few antibiotics currently available to treat NTM infections, and some patients fail to respond to any treatment at all. “
He added, “The approach that anti-malarial drugs that have already undergone advanced clinical trials could become part of the arsenal of drugs available to fight these infections could have immediate implications in the clinic.” ,” He said.
Jackson said some drugs are effective against this mycobacterium, and those that are toxic and cause bad side effects. Researchers believe that the bacterium is able to sense and respond to threats in its environment, such as low oxygen levels, oxidative stress and acidic pH, which are our bodies’ natural ways of fighting disease. It does this by, among other things, activating a regulator called DosRs that controls many essential functions in the bacterium such as its respiration, ability to form biofilms and enter a dormant state when bacteria are not conducive to multiplication. Is.
They found that in mice, two existing anti-malarial drugs were able to prevent DosRS from responding to stressors, meaning the bacteria were struggling to fight off the antibiotics and the immune system’s natural disease response.
“It blocked the regulator and prevented it from doing its job,” Jackson explained.
“One of the actions taken by the treatment, in particular, was to reduce the ability of the bacterium to form biofilms, thereby reducing its ability to resist killing by antibiotics,” he said.
Treatment alone was as effective in reducing the bacterial load in the lungs as the combination of antibiotics currently used to treat the disease.
“Treatment of M. abscessus is particularly challenging because at least three to four antibiotics are needed in combination, and there are few available options,” said Dr. Jerry Nicks, a pulmonologist at National Jewish Health.
“The reuse of antibiotics developed for other infections for use in the treatment of M. abscess has proven to be the most successful route to enhance the available treatments for this serious disease,” he said.
“This report is particularly exciting because these compounds were effective against infections and also increased the effectiveness of other antibiotics. The reuse strategy can reduce the time required to test these compounds in clinical trials. because they often have a proven track record of safety and clinical experience,” he concluded.
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