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London: AstraZeneca plc’s Covid-19 vaccine did not appear to have any adverse effects on pregnancy or fertility, according to data from a small group of trial participants who conceived during a study.
Miscarriage rates were nearly identical between the vaccinated and placebo groups, and still births or neonatal deaths were not recorded, according to results analysis. Posted in Lancetta Medical Journal late Thursday night. Fertility was also shown to be unaffected by the vaccine.
The review looked at four trials from the study spanning the UK, Brazil and South Africa. Those who were already pregnant were excluded from participating. Ninety-nine volunteers who became pregnant during the study were included in the fertility analysis – 50 who received the vaccine and 43 placebo. The results showed no effect on fertility from the shot.
A total of 107 pregnancies were evaluated for outcomes. Fifteen live births occurred during the analysis – 10 in the vaccine group and 5 in the placebo. Three babies with the vaccinated arm were born prematurely, but all were in their premature stage between 34 and 37 weeks of pregnancy.
Despite the increased risk of contracting severe Covid-19 in this population, the lack of clinical data on the effects of coronavirus vaccines in pregnancy has made pregnant people hesitant to get the shot. In England, unvaccinated pregnant women account for about 20% of critically ill coronavirus patients in hospital, National Health Service said last week.
In the UK and US, most pregnant people have been offered vaccines from Pfizer Inc. or Moderna Inc., with no safety concerns due to their widespread use globally in this group.
“With the increasing availability of misinformation that continues to affect vaccine momentum, these data, together with published data on mRNA vaccines, may provide evidence to support women in making decisions regarding vaccination, Said the authors, who are primarily the co-developers of the vaccine, the University of Oxford.
Expectant mothers are often excluded from tests due to safety concerns. Pfizer launched one earlier this year to assess the effect of its vaccine on the pregnant population, but the study was slow enrollment delay Recommendation of vaccination in pregnancy, following changes in US government guidelines. bloomberg
Read also: AstraZeneca antibody cocktail prevents Covid in high-risk groups, study finds
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