Washington: A new study of health records from 87 health care centers across the United States found that people taking a class of antidepressant called selective serotonin reuptake inhibitors (SSRIs) were less likely to die from COVID-19. The study findings were published in the journal JAMA Network Open.
The results add to a body of evidence indicating that SSRIs may have beneficial effects against the worst symptoms of COVID-19, although larger randomized clinical trials are needed to prove this.
“We can’t tell whether drugs are causing these effects, but statistical analysis is showing significant association. There is power in the numbers,” said Marina Sirota, associate professor of pediatrics and a member of the Bakker Computational Health Sciences Institute. . (BCHSI) at UC San Francisco.
The UCSF-Stanford research team analyzed electronic health records from the Kerner Real World COVID-19 De-identified Database, which contained information on nearly 500,000 patients across the United States. This included 83,584 adult patients diagnosed with COVID-19 between January and September 2020. Among them, 3,401 patients were prescribed SSRIs. The large size of the dataset enabled researchers to compare outcomes for patients with COVID-19 on SSRIs. COVID-19 patients who were not taking them were thus teased by age, gender, race, ethnicity, and the effects of serious COVID-19-associated concomitant diseases such as diabetes and heart disease, as well as the effects of other drugs. taking.
The results showed that patients taking fluoxetine were 28 percent less likely to die; Those taking fluoxetine or another SSRI called fluvoxamine were 26 percent less likely to die; The entire group of patients taking either type of SSRI was 8 percent less likely to die than matched patient controls.
Although the effects of new antivirals developed by Pfizer and Merck are less than those found in recent clinical trials, researchers said more treatment options are still needed to help end the pandemic.
“The results are encouraging. It is important to find as many options as possible to treat any condition. One particular drug or treatment may not work or may be well tolerated by everyone. Data from electronic medical records tells us This allows us to quickly look at existing drugs that can be repurposed to treat COVID-19 or other conditions,” said Tomiko Oskotski, a research scientist in Sirota’s lab at BCHSI.
Other authors include David K. of Stanford University. Stevenson, MD, Ivana Marik, PhD, Ronald J. Wong, PhD, and Nima Aghipur, PhD; and UCSF’s Alice Tang and Boris Oskotsky, Ph.D.
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