Experts find ‘master key’ to combat COVID-19 in all its forms. details here

WHO Director-General Tedros Adhanom Ghebreyesus informed on Wednesday that there has been a 35% increase in the number of reported Covid-19 deaths in the past one month, adding that 15,000 deaths were reported in the past week.

At such times, researchers claim to have discovered a vulnerability in all variants, a ‘vulnerable spot’ that could help develop more targeted ones. anti body treatment, The study, published on Thursday, has been conducted in collaboration with researchers from the University of British Columbia in Canada – led by Dr Sriram Subramaniam, a professor in the Faculty of Medicine and the University of Pittsburgh, USA – led by Drs. Mitko Dimitrov and Wei Lee. The study was published as a peer-reviewed article in the journal Nature Communications.

understanding the study

According to the published article on the study, the researchers used cryo-electron microscopy (cryo-EM) to reveal the atomic-level structure of the weak spot on the virus’s spike proteins, known as epitopes. This powerful imaging technique uses beams of electrons to visualize the shape of tissues and cells using ultra-cooling (“cryo”) techniques.

The coronavirus is 100,000 times smaller than the size of a pinhead and therefore cannot be seen under a regular microscope.

Hindustan Times Subramaniam, the antibodies bind to the virus in a specific way, “like a key going into a lock”, however, when the virus mutates, the key no longer fits. ht, Subramaniam did his MSc in Chemistry from IIT-Kanpur.

“We are looking for the master key – antibodies that continue to neutralize the virus even after it is done” widespread mutation,” He added.

Covid-19 ‘vulnerable spots’ identified

During their analysis and experimentation, the researchers found an antibody fragment VH Ab6. This fragment is known to be effective against alpha, beta, gamma, delta, kappa, epsilon and omicron variants.

According to a statement published by the University of British Columbia, VH is known to neutralize SARS-CoV-2 by binding to the epitope on the spike protein and preventing the virus from entering human cells, according to a statement published by the University of British Columbia.

“This study reveals a weak spot that is largely unchanged in various forms and can be neutralized by antibody fragments. This sets the stage for the design of pan-variant therapies that potentially have multiple can help vulnerable people,” Subramaniam, who is also the study’s senior author, said.

Utility of COVID-19 virus ‘vulnerable spot’

Subramaniam noted that this major vulnerability can now be exploited by drug manufacturers, and since the site is relatively mutation-free, the resulting treatments could be effective against existing and even future variants.

“Now we have a very clear picture of this weak spot on the virus. We know that the spike protein knows every interaction that occurs with the antibody at this site. We can work backwards from this, using intelligent design, to develop a slew of antibody therapies,” he said.

“Now that we have described the structure of this site in detail, it opens up a new realm of treatment possibilities,” he said.

covid-19 update in india

Covid-19 cases in India on Friday witnessed an upward journey with the country registering 15,754 fresh infections in the last 24 hours, two days before the daily cases remained below the 10,000 mark. With this, India’s cumulative caseload has gone up to 4,43,14,618 and active cases to 1,01,830, as per data from the Union Health Ministry.

new symptoms of covid-19 registered

The country is witnessing a steady rise in COVID-19 cases, informs medical experts Non-specific and new COVID-19 symptoms Presented by new Covid-19 patients. Till now, the common symptoms seemed to be limited to headache, fever, cough, cold, sore throat and body aches, however, patients are now reportedly presenting new symptoms.

As reported by The Economic Times, Akshay Budhraja, Senior Consultant, Respiratory and Sleep Medicine, Aakash Healthcare, said, “The number of acute coronary syndrome, myocardial infarction (heart attack) is increasing among the Covid positive patients. There are patients who report non-specific symptoms like chest pain, decreased urine output, diarrhea and then become COVID positive. After getting infected with Kovid, Kovid and his pre-existing condition is getting worse.

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