Toronto: Several studies have shown that individuals with kidney failure and undergoing dialysis have weaker antibody responses after COVID-19 vaccination, but new research indicates that the immune responses of these individuals may still be affected by SARS-CoV-2 infection. and are able to protect against serious disease.
In the study published in JASN, individuals who received a single dose of the COVID vaccine were 41 percent less likely to be infected with SARS-CoV-2 and 46 percent less likely to develop severe COVID-19, for which hospitalizations was required to be admitted. Death.
Those who received the two doses were 69 percent and 83 percent less likely to be infected or experience serious illness, respectively.
On the other hand, the non-vaccinated group had a 52 per cent risk of hospitalization and 16 per cent mortality, while the 2-dose group had a 30 per cent hospitalization risk and 10 per cent mortality.
“Patients on maintenance dialysis often have suppressed immune systems and many are unable to isolate because they must attend dialysis treatment three times per week in a dialysis center,” said Matthew Oliver from the University of Toronto in Canada.
“Reducing hospitalizations and deaths in this population is very important because about two-thirds of these patients were hospitalized and 1 in 4 died when SARS-CoV-2 started the epidemic,” he said. I got infected.”
For the study, the team analyzed the health records of 13,759 individuals who received maintenance dialysis between December 21, 2020 and June 30, 2021 – 17 percent of whom had not been vaccinated and 83 percent of whom had received at least 1 mRNA Kovid-19 vaccine dose was received. ,
They found that there was no significant difference in vaccine effectiveness between age groups, dialysis method, or vaccine type (Pfizer-BioNtech or Moderna).
“Our results show that 2 doses of the mRNA vaccine significantly protected this population, prevented many hospitalizations and deaths, and reduced the burden on patients, families and the health care system,” Oliver said.
“The effectiveness of the vaccines was lower than that seen in studies in the general population, but still provided substantial protection,” he said.
It is now recommended that all adults and adolescents, especially those who are immunocompromised, receive a third dose of the COVID vaccine to ensure an optimal immune response.
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