The two latest studies suggest that monkeypox disease has begun to hint at the asymptomatic spread of the infection which may have influenced the magnitude of the outbreak.
Findings from a retrospective study conducted in Belgium suggest that some cases of monkeypox remain undiagnosed and asymptomatic. It states that testing and quarantining persons reporting symptoms may not be enough to contain the outbreak.
Another study in France suggests that the practice of “ring post exposure” vaccination around symptomatic individuals with probable or confirmed monkeypox infection may not be sufficient to stop the spread.
Under the Ring Post Exposure Strategy, if a person is exposed to the virus, a vaccine is given to others who have been in close contact with that person, such as close family and friends.
According to experts, the findings reiterate the need for high-alert, surveillance and strategies for risk assessment and prevention against outbreaks.
first study
The findings, “Retrospective detection of asymptomatic monkeypox virus infection among attendees at a male sexual health clinic in Belgium”, suggest “the lack of recognized, clinical symptoms of virus transmission and the magnitude of 2020 monkeypox”, published in the medical journal Nature. May play a role in virus outbreak”.
“The magnitude of the 2022 multi-country monkeypox virus outbreak has surpassed that of any preceding outbreak. It is not clear whether asymptomatic or otherwise undiagnosed infections are fueling this pandemic,” said the article published on August 12.
The purpose of the article is to assess whether uncontrolled infections occurred in men attending a Belgian sexual health clinic in May 2022. The authors retrospectively examined 224 samples collected for two other diseases — gonorrhea and chlamydia — using a monkeypox virus PCR assay, and identified monkeypox DNA-positive samples from four men.
“At the time of sampling, one man had a painful rash, and three men reported no symptoms. After 21 to 37 days of clinical testing, all three of these men were free of clinical symptoms and reported not experiencing any symptoms. These findings suggest that some cases of monkeypox remain undiagnosed, and suggest that testing and quarantining individuals reporting symptoms may not be sufficient to contain the outbreak,” the article says.
second study
Another report from France was published on 16 August in the journal Annals of Internal Medicine. The aim of the study is to assess the presence of monkeypox virus in samples from asymptomatic MSM (men who have sex with men), who are routinely tested for bacterial sexually transmitted infections.
706 men visited the Infectious Diseases Department and Sexual Health Clinic of the Bichat-Claude Bernard Hospital in Paris, France, from June 5 to July 11, 2022. Of the 706 men, 383 had symptoms of monkeypox infection, and the infection was confirmed. Of the 271 with symptoms.
The report states, “Of the 187 asymptomatic participants who tested negative for the virus, 3 presented to our clinic more than 3 weeks after the initial monkeypox-negative anal swab with symptoms of monkeypox infection and tested positive.” ,” the report said.
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