Equity benchmark indices declined in early trade on April 19, extending losses for the third straight day amid a weak trend in IT counters and foreign fund outflows.
A weak trend in global markets also contributed to the negative sentiments.
The 30-share BSE Sensex closed at 59,558.13, down 168.88 points. The broader NSE Nifty closed 48.35 points lower at 17,611.80.
Among Sensex firms, Infosys, HCL Technologies, Asian Paints, Hindustan Unilever, Tata Consultancy Services, Wipro, Bajaj Finserv and Nestle were the major laggards.
The winners included Tata Steel, Axis Bank, Mahindra & Mahindra, Titan and Bharti Airtel.
In Asian markets, Japan, Shanghai and Hong Kong were trading with losses, while Seoul was trading in the green.
On Tuesday, the US markets were mostly closed with a decline.
Foreign portfolio investors (FPIs) again offloaded equities worth ₹810.60 crore on Tuesday, according to exchange data.
The 30-share BSE benchmark closed 183.74 points or 0.31% lower at 59,727.01 on Tuesday. The Nifty closed 46.70 points, or 0.26%, down at 17,660.15.
Meanwhile, global oil benchmark Brent crude fell 0.13% to $84.66 per barrel.